Group B Streptococcus (GBS) DNA microarray analysis in conjunction with qRT-PCR identified CovR activates its own expression. Visual inspection of the covR promoter region revealed one GBS-type CovR consensus sequence. EMSA using purified CovR confirmed CovR binding to its promoter.
Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.
|Site sequence||Regulated genes||Gene diagram||Experimental techniques||TF function||TF type|