Curation Information

Regulation of CovR expression in Group B Streptococcus impacts blood-brain barrier penetration.;Lembo A, Gurney MA, Burnside K, Banerjee A, de los Reyes M, Connelly JE, Lin WJ, Jewell KA, Vo A, Renken CW, Doran KS, Rajagopal L;Molecular microbiology 2010 Jul; 77(2):431-43 [20497331]
CovR [Q8DY68, view regulon]
Reported TF sp.
Streptococcus agalactiae A909
Reported site sp.
Streptococcus agalactiae A909
Created by
Grace Chandler
Curation notes

Experimental Process

Group B Streptococcus (GBS) DNA microarray analysis in conjunction with qRT-PCR identified CovR activates its own expression. Visual inspection of the covR promoter region revealed one GBS-type CovR consensus sequence. EMSA using purified CovR confirmed CovR binding to its promoter.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... csrR SAK_1638 nrdR SAK_1636 dnaI engA
Experimental technique details DNA-array expression analysis (ECO:0005525) - Experimental technique details EMSA (ECO:0001807) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - Experimental technique details Visual sequence inspection (nan) - activator not specified