Curation Information

The Leptospira interrogans lexA gene is not autoregulated.;Cuñé J, Cullen P, Mazon G, Campoy S, Adler B, Barbe J;Journal of bacteriology 2005 Aug; 187(16):5841-5 [16077133]
LexA [Q8F663, view regulon]
Reported TF sp.
Leptospira interrogans serovar Lai str. 56601
Reported site sp.
Leptospira interrogans serovar Lai str. 56601
Created by
Erill Lab
Curation notes

Experimental Process

DNAse footprinting on the recA promoter defines a 20 bp fragment protected by LexA. Site directed mutagenesis of the main elements of the perfect palindrome contained therein indicates that the palindromic bases are essential for binding.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... recA
Experimental technique details DNAse footprinting (ECO:0005631) - Experimental technique details EMSA (ECO:0001807) - Experimental technique details Site directed mutagenesis (ECO:0005667) - Experimental technique details Visual sequence inspection (nan) - repressor dimer