Curation Information

Leptospira interrogans serovar copenhageni harbors two lexA genes involved in SOS response.;Fonseca LS, da Silva JB, Milanez JS, Monteiro-Vitorello CB, Momo L, de Morais ZM, Vasconcellos SA, Marques MV, Ho PL, da Costa RM;PloS one 2013; 8(10):e76419 [24098496]
LexA [Q72P22, view regulon]
Reported TF sp.
Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
Reported site sp.
Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
Created by
Erill Lab
Curation notes

Experimental Process

UVC induction was shown with RT-PCR, although not in a LexA1- mutant. Palindromic sequences were discovered with RSAT. EMSA competition assays with each of the putative motifs showed that TTGTA-N10-TACAA was likely the binding site for LexA2.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... LIC12654 LIC12653
Experimental technique details EMSA (ECO:0001807) - Experimental technique details Motif-discovery (ECO:0005558) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor dimer