Curation Information

CcpA ensures optimal metabolic fitness of Streptococcus pneumoniae.;Carvalho SM, Kloosterman TG, Kuipers OP, Neves AR;PloS one 2011; 6(10):e26707 [22039538]
CcpA [A0A0H2ZQ65, view regulon]
Reported TF sp.
Streptococcus pneumoniae D39
Reported site sp.
Streptococcus pneumoniae D39
Created by
Elliot White
Curation notes

Experimental Process

Researchers used a consensus search of the CRE box (CcpA binding site) in the pneumoniae genome to compile a list of genes with CRE boxes in the promoter. They then cross-referenced that list with the results (trimmed to only significant results) of a DNA-array that compared wt to a CcpA deletion.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... malQ malP malX
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details DNA-array expression analysis (ECO:0005525) - activator dimer