Curation Information

Characterization of OxyR as a negative transcriptional regulator that represses catalase production in Corynebacterium diphtheriae.;Kim JS, Holmes RK;PloS one 2012; 7(3):e31709 [22438866]
OxyR [H2GUE0, view regulon]
Reported TF sp.
Corynebacterium diphtheriae C7 (beta)
Reported site sp.
Corynebacterium diphtheriae C7 (beta)
Created by
Joe Sparenberg
Curation notes

Experimental Process

lacZ reporter assay and qRT-PCR showed that OxyR represses the cat gene. EMSA performed with cat promoter fragments of various lengths and DNase I footprinting determined the location of the OxyR binding site.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type