Curation Information

The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression.;Westfall LW, Luna AM, San Francisco M, Diggle SP, Worrall KE, Williams P, Cámara M, Hamood AN;Microbiology (Reading, England) 2004 Nov; 150(Pt 11):3797-806 [15528665]
MvaT [Q9HW86, view regulon]
Reported TF sp.
Pseudomonas aeruginosa PAO1
Reported site sp.
Pseudomonas aeruginosa PAO1
Created by
Grace Chandler
Curation notes

Experimental Process

EMSA was performed on DNA fragments of varying lengths in order to localize the binding activity of MvaT. DNAse I footprinting identified the MvaT binding sequence. RT-PCR demonstrated the effect of MvaT as an activator of ptxS expression.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type