Curation Information

The NO-responsive hemoglobins of Campylobacter jejuni: concerted responses of two globins to NO and evidence in vitro for globin regulation by the transcription factor NssR.;Smith HK, Shepherd M, Monk C, Green J, Poole RK;Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2011 Aug 1; 25(2):234-41 [21199674]
NssR [Q0PB47, view regulon]
Reported TF sp.
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Reported site sp.
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Created by
Dinara Sagitova
Curation notes

Experimental Process

Regulation of ctb expression by NssR was validated by DNA microarray and qRT-PCR experiments. EMSA confirmed that NssR binds to target DNA containing the ctb promoter.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... ctb nssR Cj0467 Cj0468 Cj0469 tRNAThr tRNATyr tRNAGly tRNAThr tuf rpmG tRNATrp secE nusG rplK rplA
Experimental technique details DNA-array expression analysis (ECO:0005525) - Experimental technique details EMSA (ECO:0001807) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - Experimental technique details Visual sequence inspection (nan) - activator not specified