Curation Information

Publication
SOS response activation and competence development are antagonistic mechanisms in Streptococcus thermophilus.;Boutry C, Delplace B, Clippe A, Fontaine L, Hols P;Journal of bacteriology 2013 Feb; 195(4):696-707 [23204467]
TF
HdiR [Q5M4N8, view regulon]
Reported TF sp.
Streptococcus thermophilus LMD-9
Reported site sp.
Streptococcus thermophilus LMD-9
Created by
Erill Lab
Curation notes
-
External databases
NCBI GEO (GSE35517) http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE35517.

Experimental Process

DNA-array with a HdiR mutant identifies regulated genes. Binding sites identified by consensus search using the motif identified in S. uberus.

Transcription Factor Binding Sites


GTTAGTTTATAAACTAAC
GTTAGTTTATAAACTAAC
GTTAGTTTATAAACTAAC
GTTAGTTTATAAACTAAC
GTTAGTTTATAAACTAAC
GTTAGTTTATAAACAAAC
GTTAGTTTATAAGCTAAC
GTAAGTTAATAAACTAAC

Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
GTTAGTTTATAAACTAAC STER_0543,
... ... STER_0543 STER_0544
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details DNA-array expression analysis (ECO:0005525) - repressor dimer
GTTAGTTTATAAACAAAC STER_0076, recA
... ... STER_0076 recA
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details DNA-array expression analysis (ECO:0005525) - repressor dimer
GTTAGTTTATAAGCTAAC STER_1339,
... ... STER_1339 STER_1338
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details DNA-array expression analysis (ECO:0005525) - repressor dimer
GTAAGTTAATAAACTAAC STER_0918, rbgA, rnhB,
... ... STER_0918 rbgA rnhB STER_0921 STER_0922
Experimental technique details Consensus search (ECO:0005624) - Experimental technique details DNA-array expression analysis (ECO:0005525) - repressor dimer