Curation Information

Fur controls iron homeostasis and oxidative stress defense in the oligotrophic alpha-proteobacterium Caulobacter crescentus.;da Silva Neto JF, Braz VS, Italiani VC, Marques MV;Nucleic acids research 2009 Aug; 37(14):4812-25 [19520766]
Fur [A0A0H3C2M1, view regulon]
Reported TF sp.
Caulobacter crescentus NA1000
Reported site sp.
Caulobacter crescentus NA1000
Created by
Dinara Sagitova
Curation notes

Experimental Process

Putative Fur-binding sites in the genome of C. crescentus were detected by using a position weight matrix approach. EMSAs validated that Fur binds to the identified promoters. LacZ reporter assays validated Fur-mediated expression regulation.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... CC_3667 CC_3668 CC_3669 CC_3670 CC_3671 CC_3672 CC_3673 CC_3674 CC_3675 CC_3676 CC_3677 CC_3678 CC_3679 CC_3680
Experimental technique details Beta-gal reporter assay - Experimental technique details EMSA (ECO:0001807) - Experimental technique details PSSM site search (ECO:0005659) - activator not specified