Curation Information

The PerR regulon in peroxide resistance and virulence of Streptococcus pyogenes.;Brenot A, King KY, Caparon MG;Molecular microbiology 2005 Jan; 55(1):221-34 [15612930]
PerR [Q9A1M6, view regulon]
Reported TF sp.
Streptococcus pyogenes M1 GAS
Reported site sp.
Streptococcus pyogenes M1 GAS
Created by
Dinara Sagitova
Curation notes

Experimental Process

PerR binding site was identified by searching mrgA promoter region for a sequence similar to an experimentally confirmed PerR box. Quantitative real-time PCR analysis confirmed that PerR is a transcriptional repressor of mrgA.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... dpr SPy_1530 glcK SPy_1528 SPy_1532 SPy_1533 SPy_1534
Experimental technique details qPCR [quantitative real-time] (ECO:0005660) - repressor not specified