Curation Information

Vibrio cholerae AphA uses a novel mechanism for virulence gene activation that involves interaction with the LysR-type regulator AphB at the tcpPH promoter.;Kovacikova G, Lin W, Skorupski K;Molecular microbiology 2004 Jul; 53(1):129-42 [15225309]
AphA [H9L4T0, view regulon]
Reported TF sp.
Vibrio cholerae O395
Reported site sp.
Vibrio cholerae O395
Created by
Erill Lab
Curation notes

Experimental Process

EMSA on known site with WT and AphA mutant

The paper reports that TF forms complex with other proteins for binding with reported sites.

The manuscript elaborates on the AphA-AphB interaction.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... tcpP tcpI tcpH
Experimental technique details EMSA (ECO:0001807) - activator dimer