Curation Information

A Fur-like protein PerR regulates two oxidative stress response related operons dpr and metQIN in Streptococcus suis.;Zhang T, Ding Y, Li T, Wan Y, Li W, Chen H, Zhou R;BMC microbiology 2012 May 30; 12():85 [22646062]
PerR [A4VT39, view regulon]
Reported TF sp.
Streptococcus suis 05ZYH33
Reported site sp.
Streptococcus suis 05ZYH33
Created by
Dinara Sagitova
Curation notes

Experimental Process

The consensus sequence of the PerR-box in S. pyogenes and B. subtilis was used to screen S. suis genome for putative PerR boxes. RT-PCR was performed to validate PerR-dependent transcription regulation of the identified genes. EMSAs showed that PerR could bind to its target promoters. Regulation by PerR in S. suis was confirmed by dpr-GFP promoter fusion.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... SSU05_1689 SSU05_1690 SSU05_1691 SSU05_1692 SSU05_1693
Experimental technique details EMSA (ECO:0001807) - Experimental technique details GFP Promoter Fusion (ECO:0005636) - Experimental technique details PSSM site search (ECO:0005659) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified