Curation Information

Definition of the mycobacterial SOS box and use to identify LexA-regulated genes in Mycobacterium tuberculosis.;Davis EO, Dullaghan EM, Rand L;Journal of bacteriology 2002 Jun; 184(12):3287-95 [12029045]
LexA [A0QVY5, view regulon]
Reported TF sp.
Mycobacterium tuberculosis H37Rv
Reported site sp.
Mycobacterium tuberculosis H37Rv
Created by
Erill Lab
Curation notes

Experimental Process

Site-directed mutagenesis of M. tuberculosis promoters and analysis of their induction with mit-C when cloned in M. smegmatis (and thus via M. smegmatis LexA).

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... recA ephG Rv2739c Rv2738c Rv2737A Rv2734 Rv2735c recX
Experimental technique details Beta-gal reporter assay - Experimental technique details Site directed mutagenesis (ECO:0005667) - repressor dimer