Curation Information

Deletion of the ferric uptake regulator Fur impairs the in vitro growth and virulence of Actinobacillus pleuropneumoniae.;Jacobsen I, Gerstenberger J, Gruber AD, Bossé JT, Langford PR, Hennig-Pauka I, Meens J, Gerlach GF;Infection and immunity 2005 Jun; 73(6):3740-4 [15908404]
Fur [B3H1Z1, view regulon]
Reported TF sp.
Actinobacillus pleuropneumoniae serovar 1 str. 4074
Reported site sp.
Actinobacillus pleuropneumoniae serovar 1 str. 4074
Created by
Urooq Aqeel
Curation notes

Experimental Process

Evidence of Fur regulation through Western blots with fur mutants, iron induction and w-t. Transcriptional start-point for exbBD-tbpBA determined by RACE-PCR. High-quality Fur box observed to overlap with TSS.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... APP7_1631 APP7_1629 APP7_1633 APP7_1632 APP7_1630 APP7_1634
Experimental technique details Visual sequence inspection (nan) - Experimental technique details Western blot (quantitative) expression analysis (ECO:0000279) - activator dimer