Curation Information

The Staphylococcus aureus CsoR regulates both chromosomal and plasmid-encoded copper resistance mechanisms.;Baker J, Sengupta M, Jayaswal RK, Morrissey JA;Environmental microbiology 2011 Sep; 13(9):2495-507 [21812885]
CsoR [A0A0H3K9R5, view regulon]
Reported TF sp.
Staphylococcus aureus subsp. aureus str. Newman
Reported site sp.
Staphylococcus aureus subsp. aureus str. Newman
Created by
Erill Lab
Curation notes

Experimental Process

A CsoR homologue in S. aureus was identified by computational search (36% identical to the B. subtilis CsoR). Total RNA was extracted from wild-type and CsoR mutants and analyzed by Northen blot to show that CsoR is responsible for copper-dependent repression of copAZ and copBmco operons, and their operon configuration confirmed. The expression of other genes under low and high copper conditions in the w-t and CsoR mutant was investigated by RT-PCR, revealing repression of copAZ and clpC.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... NWMN_2457
Experimental technique details Northern blot (ECO:0005653) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - Experimental technique details Visual sequence inspection (nan) - repressor not specified