Curation Information

Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.;Schumacher MA, Piro KM, Xu W, Hansen S, Lewis K, Brennan RG;Science (New York, N.Y.) 2009 Jan 16; 323(5912):396-401 [19150849]
HipB [P23873, view regulon], [P23874, view regulon]
Reported TF sp.
Escherichia coli str. K-12 substr. MG1655
Reported site sp.
Escherichia coli str. K-12 substr. MG1655
Created by
Erill Lab
Curation notes

Experimental Process

Structure of complex HipAB with section of hipAB promoter solved verifies sequence ACTATCCCCTTAAGGGGATAG as a palidromic binding unit for the complex.

The paper reports that TF forms complex with other proteins for binding with reported sites.

HipB in complex with HipA

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... hipA hipB
Experimental technique details X-ray crystallography (ECO:0005670) - repressor dimer