Transcription factors in CollecTF

TF TF family Description TF instances
AbiEi AbiEi AbiEi is a member of a family of putative transcriptional regulators. AbiEi has an N-terminal winged-helix-turn-helix domain that is required for repression of abiE transcription, and an uncharacterized bi-functional C-terminal domain, which is necessary for transcriptional repression and sufficient for toxin neutralization [24465005]. Q8DZ36
AbrB AbrB This regulator is involved in transitioning from stationary phase to sporulation in Bacillus subtilis. It is assumed to operate as a tetramer, with a preference for TGGNA sub-motifs [20817675][11101897]
sll0359 AbrB A cyanobacterial transcriptional regulator of the AbrB-like family [19077009][PF14250]. P74426
Sll0822 AbrB A cyanobacterial transcriptional regulator of the AbrB-like family [19077009][PF14250]. Q55432
AdpA AraC/XylS AdpA, also known as BldH, is a key transcriptional regulator involved in the complex growth cycle of Streptomyces. It is a member of the AraC/XylS family regulator proteins[PF13278][PF12833]. It affects hundreds of Streptomyces genes either directly or indirectly[24694298]. Q9L062
AntR AraC/XylS AntR belongs to the AraC/XylS family of transcriptional regulators. Displaying a helix-turn-helix binding motif, AntR activates the anthranilate degradation pathway genes in Pseudomonas aeruginosa PAO1 [15466034].
AraC AraC/XylS The Escherichia coli AraC protein is the founding member of a the AraC/XylS family of transcriptional regulators [12270809]. First identified in 1959, AraC is the first-described positive regulator of transcription, activating transcription of E. coli araBAD, araFGH, araE, and araJ in the presence of l-arabinose [20491933]. AraC is made of two basic domains: the HTH DNA binding domain [PF00165] and the N-term sensing domain [PF06719]. AraC is known to bind DNA as a dimer. Dimerization is mediated by the N-term domain [8516313] and occurs among adjacent DNA sites when AraC binds arabinose. In the absence of arabinose, AraC represses transcription of araBAD and araC by forming a repression loop mediated by dimerization of distally bound AraC monomers [6089170]. A0A0F6AWN9 , P0A9E0
ArgR AraC/XylS ArgR, an AraC/XylS family transcription factor, is a regulator of genes required for arginine catabolism, uptake, and transport [15150254]. G3XCU2 , O85175 , Q9Z8Z1
BenR AraC/XylS The transcriptional factor BenR is a member of the AraC/XylS family that activates the Pb promoter in response to benzoate [22588473].
ExsA AraC/XylS [18373522] P26993
GbdR AraC/XylS GbdR, an AraC family transcription factor, regulates choline acquisition from host phospholipids in Pseudomonas species [24097953]. Q9HTI4
HrpB AraC/XylS HrpB is an AraC-type transcriptional regulator of Ralstonia with homologs in several other pythopathogens, most notably HrpX in Xanthomonas. In response to plant contact, HrpB induces the expression of TTSS genes and other virulence factors [1479894] [15060033]. It is known to target a direct repeat resembling that described for Xanthomonas HrpX (PIP motif) [15060033]. A3P7B1 , P31778
HrpX AraC/XylS HrpX is highly conserved among xanthomonads and is a member of the AraC family of regulatory proteins [10902926]. A0A0H2X9M1 , Q3BW17 , Q8PBF5 , Q9ZIP8
LcrF AraC/XylS LcrF is a member of AraC/XylS family of transcriptional regulators
MekR AraC/XylS MekR, a member of the AraC/XylS family of regulators [23771781].
OxoS AraC/XylS OxoS is a XylS family transcriptional regulator.
PchR AraC/XylS PchR is an AraC family transcription factor that regulated the expression of the pyochelin biosynthetic genes. Similarly to other AraC family regulators, PchR autoregulates its expression. [16194235] P40883
RegA AraC/XylS Involved in pathenogenesis in e. coli D2TIS0 , D5AKG8
ToxT AraC/XylS ToxT, a 32 kDa, 276-amino-acid protein, is a member of the large AraC/XylS family of transcription regulators. In ToxT, the AraC/XylS family domain consists of the 104 C-terminal amino acids. The remaining 172 N-terminal amino acids of ToxT, which presumably form a separate N-terminal domain (NTD), have unknown function. Common functions for secondary domains among other AraC/XylS family members include effector binding and multimerization. ToxT is not known to bind any effectors, although bile may be a negative regulator of its activity Our previous study of ToxT binding sites between acfA and acfD proposed a consensus DNA binding sequence for ToxT consisting of a 13 bp site with a tract of T nucleotides near the 5′ end of the site and A/T-rich sequence near the 3′ end of the site. A5F384
VqsM AraC/XylS VqsM, an AraC family transcription factor, regulates the quorum-sensing system in Pseudomonas aeruginosa [16194239]. Q9I1P2
AmrZ Arc/MetJ AmrZ, a member of the Ribbon-Helix-Helix family of DNA binding proteins, functions as both a transcriptional activator and repressor of multiple genes encoding Pseudomonas aeruginosa virulence factors. G3XCY4
Arc Arc/MetJ Arc repressors act by the cooperative binding of two Arc repressor dimers to a 21-base-pair operator site. Each Arc dimer uses an antiparallel beta-sheet (part of a family-defining ribbon-helix-helix domain [PF03869]) to recognise the (TAGA-GTGCT-TCTA) motif in the major groove [15723352]. A8CG91
CopG Arc/MetJ A plasmid-borne repressor involved in control of plasmid replication. First described in Streptococcus agalactiae plasmid pMV158 [9857196]. Shows high similarity in structure to Arc and MetJ, but has its own distinct helix-turn-helix DNA-binding motif [PF01402] P13920
HgtR Arc/MetJ HgtR is a putative member of the Arc/MetJ family with some homology to CopG. It has been identified recently in Geobacter sulfureducens as a regulator of genes involved in biosynthesis and energy generation, where it has been shown to target sites with dyad symmetry [19939938]. Q747A3
omega Arc/MetJ The omega repressor is a small (71 aa) transcription factor belonging to the MetJ/Arc superfamily. Encoded in the inc18 plasmid family, it regulates genes involved in stable maintenance of plasmids and copy number control in Gram-positive bacteria. [pmid::10639147],[pmid::11733997] Omega participates in a negative-feedback system controlling plasmid segregation: it represses the plasmid-partitioning ATPase δ [pmid::8293991], the CopR element which represses the positive regulator RepR [pmid::7533881], and itself [pmid::10639147].
ArnR ArsR ArnR is a ArsR family transcriptional regulator A4QDE6
BigR ArsR BigR, a member of the ArsR/SmtB family of metal sensors [17586627]. Q9PFB1
Enterobacter cloacae ArsR >acaacac ccggcgaatc agccttaaat ttaacggtct cagcccagtt gaataccgtc tgaaattcca tccattgcgc atttaatcag ccgattttta gttgatgcag ctttaaagaa agcgtttaaa tatgagtgat ttgtatgctc tgagttcttg cgtttaaggc taattgagtt aaagaaagcg tctggtattc gtgaccattg cgtcaccggc catcaataca tctgattttc cacatgtgtt attgatttta aattcccaga gcgtatcctg ttaccaaatg agaaggagta ctg
Escherichia coli ArsR >cccttct ccagctgaag aaatcgctaa cgcttgcaat gttagccact ggctaatagt attgaaccgt tagatgtggg cattctcact ccagccagag ccaccaactc tgggctggaa agtaaaaaac cgacgcaaag tcggtttttt tacgtcctga ttcagacctc ctttcaaatg aatagccaac gcttaattca cacctattac cttcctctgc acatacacat tcgttaaacc atatatgttt ttgacttatc cgcttcgaag agagacacta cctgcaacaa tcaggagcgc aat
HlyU ArsR HlyU belongs to the ArsR/SmtB protein family [8231807]
PyeR ArsR PyeR, a member of the ArsR family of transcriptional repressors, regulates biofilm formation in Pseudomonas aerugionsa. Unlike other ArsR regulators, it does not contain metal-binding motifs and doesn't seem to have a role in metal perception or resistance. PyeR also demonstrates the properties of an auto-repressor. [22820840] Q9HW47
ClgR ClgR/PopR ClgR is a member of the ClgR/PopR family of transcriptional regulators described in both Corynebacterium glutamicum, Streptomyces lividans and Bifidobacterium breve [16321946][15126487][15978086], where it has been shown to act as a transcriptional activator involved in the regulation of Clp complex genes. Q8NP59
PopR ClgR/PopR A member of the ClgR/PopR family of transcriptional regulators, has been shown to activate expression of clp genes in Streptomyces lividans targeting a tandem 6 bp palindromic repeat (TCTGCC-3N-GGCAGA) [11069683].
CodY CodY The global regulatory protein CodY influences the expression of many metabolic and virulence genes in Gram-positive pathogens in response to the availability of GTP and the branched-chain amino acids (isoleucine, leucine, and valine) A0A074IWI7 , A2RHP2 , B5XI03 , P39779 , Q18BE1 , Q81WK7 , Q8Y7J7
NikR CopG/NikR The Escherichia coli NikR protein was identified as a repressor through genetic studies [9882686] and later determined to be a DNA binding protein with a ribbon-helix-helix domain [PF01402] closely related to that seen in CopG. It is dimeric in solution and binds DNA in a sequence-specific manner [10595554]. B5Z8Y5 , D3UIX2 , O25896 , P0A6Z6
CopR CopY CopR repressor plays an important role in copper homoeostasis. [18837698] Q87Z28 , Q9CHA6
CsoR CsoR CsoR is a transcriptional repressor first described in Mycobacterium tuberculosis [17143269], and the founding member of the CsoR family of transcriptional regulators [PF02583]. It represses genes involved in copper resistance and homeostasis and it is a widespread regulator of copper resistance in Bacteria [24831014]. A0A0H3K9R5 , D6EK73 , O32222 , P9WP49 , Q5SHL1
RicR CsoR A CsoR paralogue in Mycobacterium tuberculosis. Binds a TACCC-N5-G/AGGTA motif and regulates copper resistance genes [21166899]. O07434
FimR DtxR/MntR family FimR belongs to the DtxR family of transcriptional regulators and regulates genes associated with fimbriation [23823757]. I1ZJY9
IdeR DtxR/MntR family IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin repressor) family [12065475] I6XF43
MntR DtxR/MntR family Mn2 homeostasis in Escherichia coli is regulated by MntR, a Mn2 -sensitive transcription factor. Mn2 stimulates the binding of MntR to the promoter of the mntH gene, which encodes the sole Mn2 transporter of E. coli. Thus, in Mn2-rich environments, MntR represses the mntH promoter,thereby shutting down the synthesis of MntH and preventing accumulation of toxic levels of Mn2. Similar systems control Mn2 uptake inBacillus subtilis, Staphylococcus aureus, Salmonella enterica serovar Typhimurium, and related bacteria P0A9F1
EspR EspR EspR is the eponymous member of the EspR family of transcriptional regulators. EspR had been characterized as a homodimer with an N-terminal DNA binding domain and C-terminal dimerization domain [21795602]. P9WJB7
AauR FIS [18310026] Q88RJ2
FIS FIS The eponymous member of the FIS family, the Factor for Inversion Stimulation was first identified in the Mu phage of Escherichia coli [3536909]. FIS is a small nucleotide-assocaited protein involved in multiple processes, such as chromosomal replication and structure. It is a global regulator that activates ribosomal-associated transcription in E. coli and it is known to self-regulate by means of 6 high affinity binding sites in its promoter region, which it binds as dimers. It is also involved in virulence regulation in Pasteurella multocida [20140235]. P0A6R3 , P57902
FlrC FIS FlrC, a Fis family, is a two-component response regulator class III flagellar genes [17981980]. Q9KQ67
NtrC FIS Fis family nitrogen metabolism transcriptional regulator. Q88CY1
Anr FNR/CRP [9350869] P23926 , Q88F34
ArcR FNR/CRP ArcR is a CRP/FNR family transcriptional regulator [11024268]. A0A0F3HTU8
Clp FNR/CRP Clp belongs to CRP/CAP (cyclic AMP receptor protein or catabolite activator protein) family of transcription factors [19749051] Q4UZF6
CRP FNR/CRP cAMP receptor protein (CRP; also known as catabolite activator protein, CAP) CRP protein binds cAMP, which causes a conformational change that allows CRP to bind tightly to a specific DNA site in the promoters of the genes it controls CRP then activates transcription through direct protein-protein interactions with RNA polymerase. The genes regulated by CRP are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system. In Escherichia coli, cyclic AMP receptor protein (CRP) can regulate the transcription of more than 100 genes. A0KST7 , A0R5H1 , O34015 , P0A2T6 , P0A2T8 , P0ACJ8 , P29281 , P74171 , Q5E2H1 , Q7CFV3 , Q7M7I9 , Q88QR4 , Q9KNW6
DNR FNR/CRP DNR (dissimilative nitrate respiration regulator)is a member of the CRP/FNR transcriptional regulators. DNR controlls the expression of the denitrification gene clusters by redox signaling [18420222] G3XCW6
FNR FNR/CRP FNR is a DNA binding protein that regulates a large family of genes involved in cellular respiration and carbon metabolism during conditions of anaerobic cell growth P0A9E5
GlxR FNR/CRP GlxR, a member of the CRP/FNR family regulator that plays an important role as a regulator of carbon source metabolism and energy conversion. [23103979] Q79VI7
HupB FNR/CRP HupB is a member of CRP family of transcriptional regulators [24858079]. P9WMK7
NssR FNR/CRP NssR, a member of the Crp-Fnr superfamily from Campylobacter jejuni, regulates a nitrosative stress-responsive regulon [16045618]. Q0PB47
NtcA FNR/CRP NtcA is a member of the CRP-family of transcriptional regulators and is prevalent and highly conserved in cyanobacteria, where it has been shown to control the response to nitrogen availability through both activation and repression. NtcA is known to bind as a dimer to target sites with consensus sequence GTAN8TAC [11133933]. Like CRP, NtcA monomers have an N-terminal effector-binding domain and a C-terminal helix-turn-helix DNA binding domain, connected by a long helix [20616047][8026471]. P0A4U6
Vfr FNR/CRP Vfr is a global regulator of virulence factor expression in the human pathogen Pseudomonas aeruginosa P55222
Fur Fur In E. coli and other prokaryotes, Fur (ferric uptake regulation) negatively regulates many genes involved in ferric iron uptake from the environment. Most Fur-regulated genes are derepressed in growth at low iron and are repressed under conditions of high iron, and in vitro DNA binding assays suggest that high levels of iron favor Fur association with DNA. Thus, Fur is considered to be an iron-dependent repressor. The classic binding motif for Fur is GATAATGATwATCATTATC, but studies have shown that Fur polymerizes at many operator sites to generate footprints that are not simple multiples of the 31 bp protected region. Further studies have revealed that Fur can even form helical arrays around the DNA strands [7991541],[12367523]. A0A0H3C2M1 , A3N1M0 , A5F6G4 , B3H1Z1 , B5Z6G7 , B6EHL8 , B7J425 , B8CQZ2 , D2BRN2 , H7C6Q1 , P0A0S8 , P0A3E5 , P0A9A9 , P0C6C8 , P33086 , P33117 , P37736 , P54574 , Q03456 , Q1CU85 , Q2FY73 , Q5E6P1 , Q5F5Y9 , Q5F961 , Q7A2F4 , Q7CQY3 , Q7VHS0 , Q820Q2 , Q87WN7 , Q8EFN3 , Q8Y5U9 , Q9ZM26
FurA Fur [17350003] Q7BR72
Irr Fur Irr, a Fur family transcriptional regulator, is an iron-responsive regulator which regulates the expression of siderophore and heme biosynthesis genes [21804001]. H7C6K3
Mur Fur Mur is a Fur family transcriptional regulator that mediates manganese-dependent regulation of the manganese uptake system [PMID::17216355 . Q92LL6
PerR Fur peroxide stress regulator A4VT39 , P71086 , P74739 , Q0PBI7 , Q2G282 , Q9A1M6
Zur Fur The zinc uptake regulator A3M333 , M9TRG5 , P0AC51 , P54479 , P9WN85 , Q0WJZ2 , Q4KKK3 , Q8NNC4 , Q8PAL3 , Q8YU81 , Q9JZ70 , Q9L2H5
BphS GntR BphS, a GntR family transcriptional regulator, involved in polychlorinated biphenyl/biphenyl degradation [11459836]. E7FJA6
FadR GntR FadR is a GntR family transcriptional regulator that controls fatty acid biosynthesis and degradation [21771112]. A5F6Z2
GtrA GntR GtrA, a GntR family transcriptional regulator.
HpaR1 GntR HpaR1 is a GntR family transcriptional regulator Q8PAI3
HutC GntR HutC is a GntR family transcriptional regulator. HutC and proteins in its respective subfamily consist of both alpha helix and beta sheet structures in the C terminal domain. In Pseudomonas putida, HutC represses histidine utilization genes [PMID:: 17714599].
LacR GntR LacR is a GntR family transcriptional regulator which negatively controls a lactose phosphotransferase system [1372602]. T1ZD52
LldR GntR LldR is a GntR family transcriptional regulator[22408166]. Q9HV39
LutR GntR A member of the GntR family of transcriptional regulators [25031425].
MatP GntR This entry contains MatP (YcbG), which is a component of the MatP/MatS site-specific system that organises the Ter macrodomain (MD) in Escherichia coli (strain K12) and related enterobacteria during replication of the chromosome. In E. coli there are 23 matS sequences, located in the Ter region which is centred on dif. The matS consensus is a palindromic sequence 5'-GTGAC[AG][CT]GTCAC, which is the recognition sequence for MatP. MatP binds to the matS sequences; and is critical for Ter MD formation. Inactivation of matP causes severe defects in chromosome segregation and cell division revealing its role as a major organiser of the Ter MD [PMID: 18984159]. P0A8N0
Mce2R GntR ORF Rv0586 is a member of the FadR subfamily of transcriptional regulators that regulates the mce2 operon, involved in virulence P9WMG5
NanR GntR NanR belongs to the FadR/GntR family of transcriptional regulators [12897000]. Q7MD38
NorG GntR NorG is a member of the GntR-like family that is associated with resistance to quinolones in Staphylococcus aureus [17277059]
PaaX GntR [21725002]
PdhR GntR PdhR is a member of the GntR family of transcriptional regulators. Functioning as a repressor in Escherichia coli, its antirepressor is pyruvate. PdhR represses the PDH pathway genes, which have a large role in the metabolic relationship between glycolysis and the citric acid cycle.[PMID:17513468]. P0ACL9
H-NS H-NS The canonical member of the H-NS family of nucleoid regulators A0A087I6S4 , P0ACF8 , Q6VQX1 , Q9KSX6
MvaT H-NS MvaT, a H-NS family transcription factor, which acts as a regulator of the mevalonate catabolism. In pseudomonas aeruginosa, MvaT is a global regulator of virulence genes expression [16570661], [19684136]. Q9HW86
HdiR HdiR The HdiR (heat and DNA-damage inducible repressor) controls a small SOS-like regulon in Lactococcus and Streptococcus species [14617183] [17513475]. This repressor has a LexA-like protease domain fused to CI-like HTH domain, instead of the winged HTH typically seen in LexA. Interestingly, the cleaved repressor is still functional (binds to its sites) and must be degraded by Clp in order for the system to be induced. A2RKI6 , B9DUC0 , Q5M4N8 , Q9CG39
IrvR HdiR This is a DNA-damage response regulator first identified in Streptococcus mutants [20038591]. It is highly similar in structure and function to HdiR from Lactococcus lactis and Streptococcus uberis [21183573]
HmgR IclR [15262943] Q88E47
HpdR IclR HpdR, an IclR family regulator in Streptomyces coelicolor, represses the tyrosine catabolic gene hppD in a substrate-dependent manner [20542930]. Q92LT2
LgnR IclR LgnR is an IclR family transcriptional regulator [24336464].
PcaR IclR An IclR family transcriptional regulator controling the beta-ketoadipate pathway in Pseudomonas putida, binds as a dimer to a 15 bp palindromic sequence [8083169]. Q88N41
TtgT IclR Summary for this TF is not yet available [17986203].
TtgV IclR Description is not yet available [17986203] V9UYV3
IHF IHF/HU The Integration host factor (IHF) was discovered as a necessary factor for bacteriophage λ integration in the E. coli genome. It binds and bends DNA, structuring DNA locally and influencing transcription of genes. It is a heterodimeric protein is composed of two homologous subunits IHFalpha and IHFbeta [16553887][1447969]. A5F1W7 , P0A126 , P0A128 , P0A6X7 , Q51472
AraR LacI/GalR AraR belongs to the LacI family of transcriptional regulators [PMID:: 24706742]. D4G1L9
CcpA LacI/GalR A pleiotropic regulator of carbon source utilization and carbon excretion pathways A0A0C6FYN7 , A0A0E2J8L1 , A0A0H2ZQ65 , A8AWB2 , F9UQH6 , G5L2G2 , H7C6V6 , N0CDN9 , P25144 , Q03AX7 , Q18AR8 , Q2G295 , Q9CF33 , S5RJF3
Cra LacI/GalR Cra (the catabolite repressor/activator) is a LacI/GalR family regulator of carbon fluxes through the central metabolic pathways of gram-negative bacteria [21239488]. Q88PQ6
MalI LacI/GalR A prototypical member of the LacI family of transcription repressors [1639817], MalI was first identified in Escherichia coli, where it is transcribed divergently from an operon containing malX and malY, involved in transport and metabolism of an as yet unidentified substrate [20141531]. P18811
NagR LacI/GalR NagR is a LacI family transcriptional regulator [20081036]. Q8EBJ8 , Q8P5C9
NfxB LacI/GalR [10984043] P32265
PtxS LacI/GalR LacI family transcriptional regulator [9645431] G3XD97 , Q88HH7
LexA LexA The LexA transcriptional repressor is the eponymous member of the LexA family. First described in Escherichia coli, LexA coordinates the expression of the SOS response by activating the expression of repair enzymes, cell division inhibitors and translesion synthesis polymerases in the advent of DNA damage [18726173] [17883408]. LexA normally represses the genes coding for all these factors by binding to their promoter region as a dimer using its Helix-Turn-Helix DNA binding domain [PF01726]. LexA usually targets palindromic sites and prevents RNA-polymerase from binding, but has been shown to target strikingly different motifs across bacteria and to sometimes activate promoters [17883408][11917014]. After DNA damage, activated RecA molecules bind LexA and promote its self-catalytic cleavage, mediated by its Peptidase S24-like domain [PF00717], inducing the SOS response. A0A072Z841 , A0A0H3NC35 , A0L9E2 , A0QVY5 , A1B3Z0 , A9BGA3 , B8CUX0 , C1F978 , D5ALN0 , I6Y1J7 , P0A153 , P0A7C2 , P0DN68 , P31080 , P37452 , P44858 , P59479 , P60511 , P61608 , P61609 , P61611 , P73722 , Q1D406 , Q2SVP7 , Q3Z9S7 , Q49848 , Q6MHM9 , Q72P22 , Q87KN2 , Q8F663 , Q8PBM1 , Q8PN77 , Q8UFK2 , Q8Y7H7 , Q8YMM5 , Q92PW3 , Q9A724 , Q9KVP9 , Q9L4P1 , Q9PH24 , Q9ZFA4
Lrp Lrp Leucine-responsive Regulatory Protein, the canonical member of the Lrp family. The E. coli Lrp regulon includes many genes that are involved in amino acid metabolism, and a smaller number of genes that play a role in pili synthesis. It exists in high copy number (~3000 Lrp dimers per cell), and frequently acts with other transcription factors P0ACJ0 , Q7MLV6 , Q9KQU4
PutR Lrp PutR is an Lrp family transcriptional regulator [8971722]. Q7MBU9
AlkS LuxR AlkS, a LuxR family transcriptional regulator, activates the expression of genes necessary for the assimilation of alkanes [10692156].
BvgA LuxR BvgA is part of the BvgAS two-component system that regulates biofilm formation in Bordetella [15317773]. It contains a GerE-type LuxR domain [PF00196]. It is known to operate as a dimer [12915094].
CsgD LuxR In Escherichia coli, CsgD has been described as a LuxR family transcriptional regulator in control of curli fimbriae production and induction of biofilm formation [17873038]. P52106
DosR LuxR DosR is a transcription factor that mediates the induction of TB genes in response to hypoxia. Sometimes referred to as DevR I6XGD8
ExpR LuxR ExpR is a member of the LuxR family of proteins. First described in Erwinia chrysanthemi, it is a quorum sensing regulator involved in biosynthesis of pectinases and glucans [9781877][18515420]. Q92L12
HapR LuxR One of the Vibrio cholerae quorum-sensing regulators; part of the LuxR family of transcriptional regulators A0A0H3Q915
LasR LuxR LasR is a member of the LuxR family of transcriptional regulators involved in quorum sensing and virulence in Pseudomonas aeruginosa [8288518]. P25084 , P54292
LuxR LuxR The eponymous member of the LuxR transcription factor family. Involved in quorum sensing regulation, and activated by an auto-inducer produced by LuxI (typically an acylated homoserine lactone). A7MXJ7 , B5EV73 , P35327
NarP LuxR Involved in regulation of the Nitrite/nitrate reductase pathway
OpaR LuxR The V. parahaemolyticus homolog of luxR Q79YV4
OryR LuxR OryR is a LuxR family transcriptional regulator [23083431]. Q5H3E9
PhzR LuxR PhzR, a protein belonging to the LuxR family of transcriptional activators [8626064]. G3XD77
RcsB LuxR RcsB, a member of the LuxR family of transcriptional regulators, is a part of a two-component regulatory system. In conjunction with RcsC, RcsB regulates the cupD usher protein operon in Pseudomonas aeruginosa. Functioning as a transcriptional activator, RcsB also senses disturbances in the outer membrane and peptidoglycan layer [20952573][19832907]. A0A0H2ZHG6
RhlR LuxR A member of the LuxR family described in Pseudomonas aeruginosa and which shares the binding motif LasR.
RsaL LuxR The RsaL protein directly represses the transcription of lasI, the synthase gene of the main quorum sensing signal molecule. RsaL belongs to the tetrahelical superclass of helix-turn-helix (H-T-H)-containing proteins. G3XD78
SalA LuxR [11843302]
SmcR LuxR Involved in regulation of virulence in Vibrio vulnificus Q7ME71 , Q7MHU7
SsrB LuxR SsrB, secretion system response regulator, is a LuxR family transcriptional regulator.
SyrF LuxR [16621822]
TraR LuxR Described in Agrobacterium tumefaciens, TraR is a homologue of the Vibrio fischeri LuxR quorum sensing regulator. It is encoded by the the tumour-inducing (Ti) plasmid and it activates the tra genes required for plasmid transfer. TraR is induced by opines and recognizes 18 bp palindromic DNA sequences [12087407]. G0KUD5 , P33905 , P54294
VpsT LuxR VpsT is a member of the LuxR family of transcriptional regulators [24363348]. A0A0H3Q9Z3 , Q9KKZ8
VqsR LuxR VqsR is a LuxR family transcriptional regulator. It had been identified as a major virulence regulator in the quorum-sensing hierarchy. [15073293] Q9I0P6
VsrD LuxR A response regulator [PF00072] of the LuxR family in Ralstonia solanacearum involved in regulation of exopolysaccharide synthesis [9573161]. Q8XVU0
XccR LuxR XccR, a LuxR-type regulator of Xanthomonas campestris pv. campestris (Xcc), activates the downstream proline iminopeptidase virulence gene (pip) in response to certain host plant factor(s) [21483448].
AmpR LysR AmpR is a global regulator of many virulence determinants and transcriptional factors. [24157832] P24734
AphB LysR Vibrio cholerae AphB (AphBVc) is a member of the LysR family of transcriptional regulators and plays a central role in the activation of the ToxR virulence cascade. AphBVc initiates the expression of the ToxR virulence cascade by directly binding to and activating the promoter of tcpPH in response to yet-unknown environmental signals. TcpPH and ToxR function cooperatively in the regulatory cascade, leading to the biogenesis of toxin-coregulated pilus (TCP) and the production of cholera toxin (CT). Q9KT56
AtzR LysR AtzR is a LysR family transcriptional regulator. Q936X4
BphR2 LysR BphR2 is a member of the LysR family of transcriptional regulators. BphR2 has been shown to activate the expression of lower pathway genes which covert salicate to acetyl coenzyme A and pyruvate in Pseudomonas pseudoalcaligenes KF707 [16788178]. I3XE46
CatR LysR CatR regulates catBC operon that encodes cis,cis-muconate lactonizing enzyme and muconolactone isomerase enzymes. These enzymes are part of benzoate metabolism pathway [PMID::7596284 ] [Q51957]. F8G324 , O32238 , Q88GK5
ClcR LysR ClcR, a LysR family transcriptional regulator, in the presence of its inducer, 2-chloromuconate, activates the expression of the biodegradation pathway for 3-chlorocatechol in Pseudomonas putida [8071232]. A0A024HKB0
CysB LysR CysB is a member of the LysR superfamily of proteins, regulating genes necessary for uptake of inorganic sulfur and cysteine synthesis. Unlike other proteins in this family, CysB is not transcribed divergently from the genes it regulates. Many LysR family regulators require an inducer molecule to activate transcription, and the inducer for CysB is N-acetyl-serine [9218775]. G3XCU6
HdhR LysR HdhR is a LysR family transcriptional regulator involved in the regulation of enzymes for haloacid detoxification in S. meliloti [22638965]. Q92Y01
LeuO LysR LeuO is a LysR-type global transcriptional regulator described in Escherichia coli and Salmonella typhi. LeuO has an N-terminal DNA-binding domain with a winged helix-turn-helix motif and a long linker-helix involved in dimerization that connects the DNA-binding domian with the C-terminal regulatory domain. Leu forms tetramers that that binds with high affinity to DNA [24659766] P10151 , P46924 , Q8Z9H8
MexT LysR LysR-family transcriptional regulator. Q9I0Z0
MvfR LysR The MvfR system, through the essential contribution of PqsE, positively regulates a subset of genes dependant on both LasR and RhlR. V6AIV4
NodD1 LysR NodD1 belongs to the LysR family of transcriptional activators. In Sinorhizobium meliloti, it has been shown to activate expression of nod genes, with this activation stimulated by flavonoids [16855231]. P03031
OxyR LysR OxyR A0A0H3CCL0 , H2GUE0 , M4U7P6 , Q7CL10 , Q88C74 , Q8PCA2 , Q9HTL4 , Q9K1H8
PA2206 LysR PA2206 is a LysR-type regulator involved in response to oxidative damage as well as host (plant&animal) interactions. It targets a canonical LysR-type binding site and regulates at least one other operon in P. aeruginosa [23382903]. Q9I1R1
PcaQ LysR PcaQ, a LysR family regulator, induces the expression of the protocatechuate catabolic genes, pcaDCHGB, in Agrobacterium tumefaciens and S. meliloti [PMID:21700663]. Q92TL9
PhcA LysR PhcA is a LysR-type transcriptional regulator of EPS synthesis and other virulence factors, first described in Ralstonia solanacearum. Its activity is controlled by a quorum-sensing system with a unique autoinducer, 3-hydroxy palmitic acid methylester [8366033][9383151]. P52698
PltR LysR ​PltR is an activator of the LysR family of transcriptional regulators. In Pseudomonas aeruginosa, PltR has been observed to activate the pyoluteorin biosynthesis operon. [22761817] B3G2A3
PtxR LysR PtxR, a LysR family activator, is commonly observed to control exotoxin A regulation. In Pseudomonas aeruginosa, PtxR has been shown to be involved in the transport and conversion of 2-ketogluconate into 6-phosphogluconate to be used in the Entner-Doudoroff pathway [10383985] [22844393]. P72131
PycR LysR PycR, a member of the LysR family of transcriptional regulators, has pleiotropic effects on virulence factors. With a predicted helix-turn-helix binding domain, it exhibits typical LysR motifs. In Pseudomonas aeruginosa, it has been shown to activate the expression of lipase, esterase and biofilm production.[PMID: 18599838]
QscR LysR QscR (Quayle serine cycle regulation), a LysR-Type Transcriptional Regulator, is a major regulator of the serine cycle. [12562792]
RovM LysR RovM is a LysR-type transcriptional repressor. RovM represses the transcription of the RovA transcription factor in Yersinia pseudotuberculosis, indirectly controlling virulence factors. [17074075]. Size exclusion chromatography has shown that RovM binds as a tetramer [21245528]. Q0WF12
SalR LysR SalR is a member of the LysR transcriptional regulator family and positively regulates the expression of salicylate hydroxylase [11298739].
TcbR LysR TcbR is a member of the LysR family of transcriptional regulator. TcbR is an activator of chlorocatechol oxidative operon. TcbR shares a high degree of homology with other activator proteins involved in regulating the metabolism of aromatic compounds [2050630].
TrpI LysR [2107533] P11720
AlgR LytR A virulence factor response regulator, canonically in P. aeruginosa. P26275 , Q500P4
AphA MarR/SlyA Two activators encoded by unlinked genes, AphA and AphB, regulate the transcription of tcpPH. AphA is a dimer with an N-terminal winged-helix DNA binding domain that is structurally similar to those of MarR family transcriptional regulators. AphA cannot activate transcription of tcpP alone, but requires interaction with the LysR-type regulator AphB that binds downstream of the AphA binding site A7MXA8 , H9L4T0 , Q7MMB6 , Q87L53
ExpG MarR/SlyA A member of the MarR family of regulatory proteins, ExpG is a transcriptional activator. ExpG induces expression of galactoglucan biosynthesis genes in Sinorhizobium meliloti [15632443].
MexR MarR/SlyA [18757728] P52003
OhrR MarR/SlyA OhrR, a transcription factor that responds to the presence of reactive oxygen species, is a member of the MarR family of transcriptional regulators and is widely conserved among Gram-negative and Gram-positive bacteria. It binds as a dimer, but since it binds with variable spacing, sites are reported as monads. A9CJU2 , M4TR54 , Q8EI70 , Q92MX6 , Q9HZZ4
PecS MarR/SlyA Regulator, involved in regulation of virulence factors and pectic enzymes in Erwinia chrysanthemi. Dimer.
PqrR MarR/SlyA [19717597] Q9I516
RovA MarR/SlyA A member of the MarR/SlyA family of transcriptional regulators that control the virulence of multiple bacterial pathogen, RovA is required for the virulence of all three pathogenic yersiniae (Y. pestis, Y. pseudotuberculosis, and Y. enterocolitica) through regulation of various virulence loci. B1JJ73
SlyA MarR/SlyA SlyA, a MarR family transcriptional regulator, controls an assortment of biological functions in several animal-pathogenic bacteria. E0SG24
WggR (ExpG) MarR/SlyA WggR belongs to the MarR family of transcriptional regulators. The previous name for this transcription factor was ExpG. Acting as an activator, WggR positively regulates EPS II synthesis genes in Sinorhizobium meliloti [22912712]. P96440
YodB MarR/SlyA YodB, a member of the MarR/DUF24 family of transcription factors, also shares a similarity to members of the ArsR family of regulators. Containing a winged-helix motif, its main distinction from the ArsR family is its lack of conserved cysteine residues in the HTH motif. In Bacillus subtilis, YodB has been shown to act as a repressor of spx. [17158660]. YodB has also been shown to repress expression of the catechol dioxygenase catE in Bacillus subtilus [20639328]. O34844
BrlR MerR BrlR is a a member of the MerR family of transcriptional regulators. BrlR plays a role in the antimicrobial tolerance of biofilms. [22730129] Q9HUT5
CorR MerR [17560604] Q87W60
CueR MerR CueR is a MerR-family copper efflux transcriptional regulator. [12829265] A0A0F6AXY2 , P0A9G4 , Q9HV30
GolS MerR [21153861]
HnoC MerR HnoC is a repressor from the MerR superfamily of transcriptional regulators. In Shewanella oneidensis MR-1, HnoC has been shown to repress signaling genes in the hno network [21624143]. Q8EE50
SoxR MerR SoxR, a homodimeric protein that belongs to the MerR family of transcriptional regulators, senses superoxide-generating compounds via the one-electron oxidation of its [2Fe-2S] cluster. [22056938] Q8P6Y4
MogR MogR MogR is a transcriptional repressor in Listeria monocytogenes that regulates flagellar motility genes by binding as a dimer to AT-rich palindromic sequences [19446532][16617375][PF12181] P0DJO8
RdgB Mor/C RdgB is a bacterial transcriptional activator described in Erwinia carotovora with high similarity to bacteriophage Mu Mor protein, a founding member of the Mor/C family. [9084157][7715460] Q47588
Rep Mor/C Repressor protein C (or Rep), encoded by repC, in phage Mu represses the Pe (early) promoter and blocks the expression of the genes required for replication (lytic growth) [PF02316] [16154589]
FixJ NarL/FixJ The 'two-component' transcriptional activator FixJ controls nitrogen fixation in Sinorhizobium meliloti [PMID: 15256575]. P10958
FruA NarL/FixJ FruA is a member of the NarL/FixJ family. It is a transcription factor essential for development in Myxococcus xanthus, required for the execution of aggregation, fruiting body formation, and subsequent sporulation [16040607]. Q1D7Q3
GacA NarL/FixJ GacA is an antibiotic production regulator of the FixJ family of two-component regulators. In this two-component system, the second component is GacS. GacA contains two functional domains. The first domain is an amino terminal phosphorylation-induced activator domain, and the second is a carboxy-terminal output domain. The output domain is characterized by a helix turn helix DNA binding motif [9852008] [8002569]. Some evidence suggests that GacA may function as a global regulator of the secondary metabolism in Pseudomonas fluorescens [1311842].
NarL NarL/FixJ A response regulator for nitrogen metabolic pathways P0AF28 , Q9HXD3
StyR NarL/FixJ [12670500]
TodT NarL/FixJ ​TodT, a member of the NarL family of transcriptional activators, is part of a two component regulatory system with TodS. This pathway encodes for genes responsible for the degradation of toulene, benzene and ethylbenzene. ​TodT demonstrates a helix-turn-helix binding motif. [PMID:: 18166197] I7CA98
AlgB NtrC/DctD A member of the NtrC family, AlgB is a two-component response regulator. AlgB belongs to a subfamily of NtrC proteins which can activate promoters that use sigma factors other than sigma 54. In Pseudomonas aeruginosa, AlgB has been shown to activate the production of alginate [17981963].
CbrB NtrC/DctD CbrB is part of a CbrA/CbrB two-component system involved in catabolite repression [17545289]. Q9HV73
DmpR NtrC/DctD DmpR belongs to the NtrC family of transcriptional activators. In Pseudomonas sp. DmpR has been observed to control the phenol catabolic pathway.[8449869]
FleQ NtrC/DctD FleQ is a c-di-GMP-responsive transcriptional regulator in Pseudomonas aeruginosa. FleQ is known to activate expression of flagella biosynthesis genes. G3XCV0 , Q8P9D2
FlrA NtrC/DctD FlrA, an NtrC-like transcriptional regulator, is required for flagellum-mediated motility [14960570].
GnfM NtrC/DctD A transcriptional regulator of nitrogen-fixation described in Geobacter sulfurreducens. It is part of a two-component system consisting of the histidine kinase GnfL and the response regulator GnfM [20660485] Q74EF9
HbpR NtrC/DctD HbpR, an NtrC family regulator, a key regulator for 2-hydroxybiphenyl metabolism [10629187]
HrpR NtrC/DctD [14651344]
HrpS NtrC/DctD [14651344]
LuxO NtrC/DctD A homolog of NtrC, LuxO regulates quorum sensing in Vibrio harveyi, acting in concert with sigma54 [10844680]. A0A0H0Y234 , A7MVC2
PhhR NtrC/DctD In contrast with most members of this family of regulators, transcription from the promoter of the phhAB operon (P(phhA)) is mediated by RNA polymerase with sigma(70) rather than with sigma(54). A0A0C7D413 , Q88EH4
PilR NtrC/DctD First described in Pseudomonas aeruginosa, PilR is a transcriptional activator of pilin genes that belongs to the NtrC family of two component sensor-regulators [7715443] [PF00072]. It has been reported to bind three short direct repeat sequences. Q74D24
SypG NtrC/DctD SypG is a member of the NtrC family of transcriptional regulators [24097942]. Q5DYQ0
TouR NtrC/DctD TouR is a NtrC family transcriptional activator of the components of the toluene and o-xylene catabolic pathway [10473416] [15489447].
VpsR NtrC/DctD VpsR is a two-component response regulator of the vps biosynthetic gene cluster, which plays a role in the formation of biofilms in Vibrio Cholera. [11160103] Q9KU59
XylR NtrC/DctD XylR is an activator from the NtrC family of transcriptional regulators. XylR is known to activate the TOL catabolic pathways, which control the degradation of toluene and related aromatic compounds. In Pseudomonas putida, XylR binds to RpoN-dependent promoters. [8132529][1579469] Q9A3Y5
ArcA OmpR/PhoB When oxygen availability is low, the membrane-bound sensor, ArcB, is autophosphorylated and activates ArcA by transfer of the phospho-group. ArcA phosphorylation initiates a change in oligomeric state, resulting in DNA binding. ArcB does not sense oxygen directly but is thought to sense the redox state of the ubiquinone/ubiquinol pool in the aerobic respiratory chain because ubiquinone inhibits ArcB autokinase activity. It has also been shown that metabolites associated with fermentation (e.g. the reduced fermentation products acetate, d-lactate, pyruvate, and NADH) inhibit the ability of ArcB to dephosphorylate ArcA . Thus, when the ubiquinone pool is more oxidized and the concentrations of fermentation products are low (i.e. aerobic respiratory conditions), ArcBA is switched off. [21252224] P0A9Q1 , Q5E2Y1 , Q8EAB9
ArsR OmpR/PhoB ArsR is an OmpR family transcriptional regulator [16713649]. O24973
CadC OmpR/PhoB PFam search using CadC sequence suggests that CadC is most closely related to the OmpR family. Update if new information becomes available
ChvI OmpR/PhoB ChvI, an OmpR family two-component response regulator. ExoS/ChvI regulate succinoglycan production, biofilm formation, motility, nutrient utilization [PMID:19749054]. P50350
CiaR OmpR/PhoB CiaR belongs to the OmpR family of transcription factors. CiaRH two-component regulatory system is found in all streptococcal species [21106082]. Q8DU28
ColR OmpR/PhoB OmpR family transcriptional regulator. Q88PE9
CosR OmpR/PhoB CosR (Campylobacter oxidative stress regulator) is an OmpR family response regulator in the oxidative stress defense [PMID::21811584 ] . Q0PBF4
CovR OmpR/PhoB CovR(CsrR) is a global transcriptional regulator from the OmpR family. CovR has a two-domain structure, with both a DNA-binding domain and a receiver domain, which are separated by a flexible linker [17376070]. In Streptococcus pyogenes, it has been shown to activate dipeptide permease promoters while also repressing around 15% of the genome [16963575]. I6L8Z5 , Q1J8D4 , Q8DY68
CpxR OmpR/PhoB An OmpR family two-component response regulator.
CtrA OmpR/PhoB CtrA is a member of the OmpR family of winged helix-turn-helix response regulators. The activity of C. crescentus CtrA, like OmpR and other response regulators (The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control41), is dependent on phosphorylation at a conserved aspartate residue. Response regulators and histidine kinases, the elements of two-component signal transduction systems, mediate a wide range of adaptive responses in bacteria. CtrA, like many response regulators, has a DNA-binding domain. The phosphorylated form of CtrA has been shown to act as a transcription factor that directly regulates genes involved in cell division, DNA methylation, flagellar biogenesis, and pili biogenesis (The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control5–The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control); it has also been shown to repress initiation of DNA replication by binding to five sites in the origin of replication (The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control). The cell cycle-regulated expression of these CtrA target genes is effected by changes in active CtrA levels during the cell cycle P0CAW8 , Q7APB9 , Q82ZN7
GlnR OmpR/PhoB GlnR, an OmpR family regulator [24931311] A4FQD5
NrrA OmpR/PhoB Belonging to the OmpR family of transcriptional regulators, NrrA is a nitrogen-related transcription factor. NrrA is activated in nitrogen-deprived conditions by the global nitrogen regulator NtcA [21926170]. In the cyanobacterium Anabaena, NrrA activates the expression of genes involved in heterocyst development [17041048]. K7WA79
OmpR OmpR/PhoB OmpR is the canonical protein in the OmpR family A1JSH8 , P0AA16 , Q7CFX0
PhoB OmpR/PhoB PhoB, an OmpR/PhoB family transcription factor, is a part of PhoB/PhoR two-component regulatory system which controls the pho regulon. PhoB regulates phosphate stress-controlled synthesis of the membrane lipid diacylglyceryl-N,N,N-trimethylhomoserine [10216860]. M4MSP4 , P23620 , Q3K4G1
PhoP OmpR/PhoB PhoP and PhoQ constitute a classic regulatory two-component system. The sensor protein PhoQ responds to low environmental Mg2+, acidic pH, and host-secreted antimicrobial peptides, and then phosphorylates the response regulator PhoP. As a transcription factor, phosphorylated PhoP either activates or represses its target genes through binding to their promoter-proximal DNA regions. The PhoQ protein is a sensor for extracytoplasmic Mg2+ that modifies the phosphorylated state of the DNA-binding protein PhoP. The PhoP protein controls the expression of a large number of genes that mediate adaptation to low Mg2+ environments and/or virulence in several bacterial species including Salmonella enterica, Shigella flexneri, Yersinia pestis, Erwinia carotovora, Neisseria meningitidis, Photorhabdus luminescens and Escherichia coli. A0A0B6P4W3 , I3NI96 , P0DM78 , P23836
PmrA OmpR/PhoB [PMID::xxxx] Q8Z1P4
Rem OmpR/PhoB Rem, an OmpR family transcriptional regulator, controls motility and chemotaxis genes in Sinorhizobium meliloti [20203055]. F7X8H2
RhpR OmpR/PhoB Regulates T3 genes in Pseudomonas syringae Q883X4
SO2426 OmpR/PhoB SO2426 is a member of the OmpR/PhoB family of response regulators. Characteristic of this family, SO2426 has a predicted winged helix-turn-helix binding motif [18718017]. In Shewanella oneidensis MR-1, SO1416 has been shown to activate siderophore expression [21624145]. Q8EEF6
TcpP OmpR/PhoB ToxR and TcpP are homologous to the OmpR family of transcriptional activators. Unlike many OmpR family activators, both proteins contain DNA-binding motifs in their N-termini rather than in their C-termini, and both are predicted to reside within the inner membrane of the bacterium with substantial periplasmic domains. In addition, both toxR and tcpP are encoded in polycistronic operons with downstream genes (toxS and tcpH respectively) encoding effector proteins that enhance the activity of their cognate partners. Q93TT6
TorR OmpR/PhoB TorR belongs to the OmpR family of response regulators. Q8EHJ3
ToxR OmpR/PhoB ToxR and TcpP are homologous to the OmpR family of transcriptional activators. Unlike many OmpR family activators, both proteins contain DNA-binding motifs in their N-termini rather than in their C-termini, and both are predicted to reside within the inner membrane of the bacterium with substantial periplasmic domains. In addition, both toxR and tcpP are encoded in polycistronic operons with downstream genes (toxS and tcpH respectively) encoding effector proteins that enhance the activity of their cognate partners. A0A0H3AK48
VirG OmpR/PhoB The response regulator of the VirA/VirG two-component system in Agrobacterium tumefaciens; mediates the expression of virulence genes in response to plant host signals.
Phd Phd/YefM Phd is the antitoxin of the Phd-Doc system [10358024]. First described in bacteriophage P1, this plasmid addiction system has two proteins: the Doc (death on cure) toxin and the antitoxin Phd (preventhost death) [8411153]. Phd has a DNA-binding domain and self-regulates expression of the phd-doc operon [15743936]. P40819
DinJ RelB The DinJ antitoxin is associated with toxin YafQ, an endoribonuclease that inhibits translation [17263853], and binds DNA to self-regulate the dinJ-yafQ operon [19210620]. Q47149 , Q47150
RelB RelB RelB is a ribbon-helix-helix (RHH) repressor encoded by the relBE toxin-antitoxin locus of Escherichia coli capable of neutralizing the toxicity of RelE and of binding to the relBE operon in a complex with RelE [19747491]. P0C077 , P0C079
RovS Rgg RovS is a Rgg family transcriptional regulator [16988238]. Q8E7C5
HexR RpiR HexR is a RpiR family transcriptional regulator. It is involved in glucose metabolism in Pseudomonas putida [19506074]. Q88P32 , Q8EE97
IolR RpiR An RpiR-family transcriptional regulator encoding a SIS (Sugar ISomerase) domain [01380] and involved in regulation of regulation of myo-inositol catabolism in Caulobacter crescentus [19096521]. M4MS71 , Q9A8Q6
IscR Rrf2 IscR is an iron-sulfur cluster transcriptional regulator. [11742080] Q667Y0 , Q9HXI7
NsrR Rrf2 NsrR is a member of the Rrf2 family of putative transcription regulators [15458412]. Q5E2D6
MgrA SarA MgrA is a protein of the SarA/MgrA family, related to the MarR family, that operates as a homodimer and has a direct regulatory role in virulence and antibiotic resistance in Staphylococcus aureus [16980961][22927394].
SarA SarA The eponymous member of the SarA family. Described in Staphylococcus aureus, SarA upregulates the expression of fibronectin and fibrinogen binding proteins and toxins and donwlregulates expression of proteases. It is hence a transcriptional regulator involved in virulence. SarA is a dimeric winged helix protein [17464068][10411747]. Q5HI51
RpoN Sigma 54 The bacterial rpoN operon codes for sigma 54, which is the key sigma factor that, under nitrogen starvation conditions, activates the transcription of genes needed to assimilate ammonia and glutamate. P0A171 , P24255 , P26979 , P49988 , Q74BZ1 , Q9KP49 , Q9PDH1
AlgU Sigma 70 [7961421] Q06198
HrpL Sigma 70 HrpL is an alternate (ECF) sigma factor of the sigma 70 family [04542]. First reported in Pseudomonas syringae, it is involved in the activation of hprD as well as other hrp loci which are involved in plant pathogenicity, hrmA and avr genes [8106313]. G3XDC4
PvdS Sigma 70 The alternative sigma factor PvdS is essential for the expression of all other pyoverdine synthesis genes [11222621]. PvdS in P. aeruginosa is regulated in response to iron concentration in the growth media via the ferric uptake regulator, Fur [18363796]. G3XCV1 , Q884G0
RpoE Sigma 70 RNA polymerase sigma factor RpoE [24733097] Q9KPA6
RpoS Sigma 70 RpoS is the sigma 38 subunit of the RNA-polymerase regulating stationary phase genes (response to nutrient deprivation) in Escherichia coli [21639793]. RpoS is a member of the sigma 70 family [3092189]. O51712
SigA Sigma 70 Belonging to the Sigma 70 family of transcriptional regulators, SigA serves as a transcriptional activator. In Rizobium etli, SigA activates the transcription of an active reporter gene [16528104].
Spo0A Spo0A The Spo0A is activated through phosphorylation by several different kinases and activates the entry into the sporulation pathway [11286862][PF08769]. Q18B74
BreR TetR Bile REsponse Repressor (BreR) is the negative regulator of the breAB (formerly vexCD) operon in Vibrio Cholerae, whose repression is relieved in the presence of bile. [18776020] Q9KR96
CamR TetR CamR is a TetR family transcriptional regulator that represses the camphor degradation pathway [8253671].
CifR TetR CifR, a TetR family transcription factor, is an epoxide-responsive repressor [18458065]. Q9HZR6
CmeR TetR CmeR belongs to the TetR family of transcriptional regulators [17183170]. Q0PBE2
DesT TetR DesT, a TetR superfamily regulator, is a repressor of the components of an oxidative Δ9 acyl-CoA desaturase system [20941840]. Q9HUS3
LuxT TetR A TetR-type repressor. Q7MFA2
Mce3R TetR Mce3R is a transcriptional repressor of the TetR family described in Mycobacterium tuberculosis [19389781] that controls a regulon involved in lipid metabolism.
MexL TetR MexL, a TetR family transcription factor, is a repressor of a two-component RND pump for triclosan efflux [12193619]. Q9HXW2
MexZ TetR [19589837] G3XCU9
NalD TetR NalD, a TetR family transcriptional regulator, negatively regulates the expression of mexAB-oprM multidrug resistance efflux system [17028276].
NicR2 TetR The repressor NicR2 belongs to the TetR family of transcriptional regulators. Although NicR2 contains a conserved helix-turn-helix binding motif, it behaves differently than other helix-turn-helix binding proteins. Most other binding proteins with this motif bind to palindromes as homodimers while NicR2 binds as a tetramer with one dimer occupying one half-site. In Pseudomonas putida, NicR2 has been shown to repress the expression of a nicotine degradation gene cluster [ PMID: : 24471758 ].
PhlF TetR The PhlF transcriptional repressor is a member of the TetR family. In Pseudomonas fluorescens, it represses the transcription of genes responsible for biosynthesis of the antifungal metabolite PHL. [24006471][12003942] It exhibits a helix-turn-helix DNA binding domain. [PMID::10708392 ] G8QCB1
Pip TetR [16997957]
PsrA TetR PsrA is a TetR family transcriptional regulator [11914368]. Q4KFB4 , Q87ZC1 , Q88KZ5 , Q9HZJ9
RutR TetR The rutABCDEFG operon, that encodes genes for the catabolism of pyrimidines, is regulated by RutR, a TetR family factor whose DNA binding is modulated by uracil P0ACU2
SczA TetR SczA is a TetR-family regulator [PF00440] involved in the regulation of intercellular transition-metal ions and has demonstrated Zn2+ dependent activation of genes involved in Zn2+ resistance [17640279]. Q8DNK2
SlmA TetR SlmA is a TetR family transcriptional regulator [PMID::21113127 ]
TtgR TetR TtgR is a TetR family transcriptional regulator [14506010]. Q9AIU0
Sxy TfoX The Sxy protein is involved in natural competence regulation in the Gammaproteobacteria, where it acts as a co-regulator with the cAMP receptor protein (CRP), modifying its natural target binding motif [17068078][18761017].
UmuDAb UmuDAb The UmuDAb protein has been described in Acinetobacter baumannii as a variation of the standard UmuD protein, which associates with UmuC as the translesion synthesis polymerase V. Most likely through a non-conserved N-term DNA-binding motif, UmuDAb has been shown to bind palindromic sites in the promoters of the genes it regulates, and to operate also as a translesion synthesis polymerase in this organism [24123815][24342640].
WhiA WhiA WhiA is essential for sporulation in Streptomyces.
BldD XRE BldD transcription factor possess a characteristic HTH DNA binding domain of the XRE family of regulators [PF01381]. BldD is an essential regulator of the developmental process in Streptomyces coelicolor [22092088]. A4FBF9 , B1W457 , Q7AKQ8
BswR XRE BswR, a xenobiotic response element-type transcriptional regulator, takes part in the regulation of bacterial motility and biofilm formation in P. aeruginosa. Q9I063
HipB XRE The HipB antitoxin belongs to the XRE family of transcriptional regulators. It is expressed in an operon with the high-persistence (HipB) toxin, which it self-regulated in complex with it [25056321]. P23873 , P23874